Adderall offers great medical benefits to ADHD patients, but Adderall neurotoxicity is also a well-known fact. Various studies suggest that Adderall is explicitly neurotoxic to the dopamine neurotransmitters as the latter are pretty susceptible to oxidative strain. That is why amphetamines (Adderall’s constituents) may be neurotoxic in due course since it can cause severe damage to the dopamine neurotransmitters in your brain.
Dopamine controls pleasure, reward, well-developed tone, and motivation. Adderall enhances alertness by increasing the levels of norepinephrine and dopamine in your brain. As a result, dopamine might auto-oxidize to create 6-OHDA (6-hydroxydopamine) that can damage dopamine nerve cells.
Dopamine neurotransmitters are quite susceptible to oxidative strain because of their . Various studies reveal that Adderall abuse can result in Parkinson’s disease. It is because of the damage to the dopamine neurotransmitters, and the lower levels of dopamine in your brain.
Neurotoxicity is the primary reason behind brain damage. It plainly means damage to the PNS (Peripheral Nervous System) or the brain due to the toxic drugs. These medicines may upset your nervous system by destroying the brain neurons. The brain neurons are necessary for data processing and information transfer all over your brain as well as various other regions of your nervous system.
Adderall contains amphetamine which can improve brain functionality by enhancing the norepinephrine and dopamine levels in your brain. These neurotransmitters trigger the pleasure feelings. However, amphetamine can be neurotoxic to the dopamine neurotransmitters. It can result in the destruction of these neurotransmitters, and lower the levels of dopamine in your brain.
As mentioned previousy, recent studies suggest that amphetamine abuse can also lead to the risk of Parkinson’s disease. The condition apparently occurs because of Adderall neurotoxicity. It means damage to the dopamine nerve cells or nerve connections, and large-scale reduction of dopamine levels in your brain.
The studies further suggest that Adderall, at therapeutic doses, won’t destroy dopamine nerve cells. But long-term amphetamine usage can reduce the levels of endogenous antioxidants. It can lead to continuous degradation of the enzyme called tyrosine hydroxylase which helps in the biosynthesis of dopamine. It may further decrease the levels of both BDNF (Brain Derived Neurotropic Factor) and NGF (Nerve Growth Factor) in the brain. All such cellular activities may result in Adderall neurotoxicity.
Vitamin C: Vitamin C acts as a blood-brain-barrier porous antioxidant, which apparently soothes the symptoms of Adderall neurotoxicity. It might assist in the acidification of urine, which, in turn, can lead to the clearing of Adderall. Furthermore, vitamin C is necessary for the synthesis of dopamine. For that reason, the intake of vitamin C supplements may help to alleviate Adderall neurotoxicity.
Vitamin D3: Recent studies reveal that Vitamin D3 can improve GDNF (Glial cell-line Derived Neurotrophic Factor). Furthermore, GDNF hinders the destruction of dopamine neurotransmitter. This action is stimulated by 6-OHDA (6-hydroxydopamine).
Hypothermia: Amphetamine tends to trigger hyperthermia. Therefore, you need to avoid excessive workouts so that your body remains cool. Hypothermia tests conducted on patients with brain disorders has yielded positive results in the past. It indeed helped in the treatment of various brain conditions, such as stroke and TBI (Traumatic Brain Injury). Numerous studies suggest that brain cooling can slow down its metabolic rate, which can result in reduced energy needs and decreased creation of ROS (Reactive Oxygen Species). Consequently, keeping your body cool can alleviate Adderall neurotoxicity.
NSAIDS: NSAIDS (Non-Steroidal Anti-Inflammatory Drugs) can assist in alleviating Adderall neurotoxicity. However, you need to consult your doctor first and foremost before opting for these drugs. NSAID can diminish the risk of Parkinson’s disease, and guards against 6-OHDA (6-hydroxydopamine) neurotoxicity as well as Adderall neurotoxicity to dopamine neurotransmitters.
Magnesium: Magnesium is a vital supplement and plays a significant role of a partial NMDA antagonist. NMDA antagonists guard your brain against various types of damage, such as NMDA neurotoxicity and glutamate cytotoxicity. Also, magnesium can effectively neutralize tolerance to amphetamines. As a result, you don’t have to increase the amount of your daily Adderall dosage. However, you must not take magnesium simultaneously with Adderall dosage. And, the most appropriate time to take magnesium supplement is right before you go to sleep during nights.
Avoid Simultaneous Alcohol Intake: Avoid taking alcohol along with Adderall dosage. The simultaneous intake of alcohol can result in Adderall neurotoxicity as it can forcefully hinder the activities of aldehyde dehydrogenase enzyme. This enzyme metabolizes toxic elements such as DOPAL (dihydroxy phenylacetaldehyde). DOPAL is one of the primary reasons behind dopamine depletion in your brain. Stopping the activities of aldehyde dehydrogenase enzyme can result in the re-accumulation of DOPAL.
Green Tea: Green tea phytochemicals are ideal for your neural system. To alleviate Adderall neurotoxicity, you can sip a cup of hot green tea along with your daily Adderall dosage. Phytochemicals are naturally rich compounds which exist in plants such as flavonoids and polyphenols. These powerful agents can alleviate Adderall neurotoxicity and other neural disorders by destroying pathological accumulations of ROS (reactive oxygen species) and RNS (reactive nitrogen species). Furthermore, it creates a chelate with neurotoxic substances. That is how phytochemicals guard dopamine neurotransmitters against Adderall neurotoxicity along with other neurotoxins such as 6-OHDA, rotenone, and MPTP.
Other Nootropic Supplements: There are many nootropic supplements available in the market which many physicians consider as safer alternatives to Adderall. These include Piracetam, Aniracetam, Pramiracetam, and Adrafinil. These nootropic supplements have minimum side effects, withdrawal symptoms, tolerance, overdoses issues or addiction. These can, indeed, improve overall cerebral health and brain functionality.
Adderall is undoubtedly a potent drug in the short-term; however, it also comes with certain potential side effects. Therefore, its users need to consult a physician before opting for this drug. Also, they should precisely use it infrequently or according to the prescription. If you don’t wish to deal with Adderall’s potential side effects, including Adderall neurotoxicity, then you can choose any of the nootropic supplements mentioned above.
These supplements are a safer alternative to Adderall and can immensely help to improve memory and increase focus span. Several past Adderall users are consistently opting for nootropic supplements like Piracetam, Aniracetam, and Adrafinil. And they are gaining many cognitive benefits like enhanced motivation, improved attention and great cerebral energy without any side effects. These nootropic supplements also work as neuroprotective and provide superior and long-lasting brain health.