Both Alpha GPC and Citicoline (CDP Choline) nootropics belong to the choline family and directly work on the cholinergic system. The human cholinergic system is otherwise known as PNS (Parasympathetic Nervous System).
A small section of nootropic users who constantly use Alpha GPC or Citicoline have reported of experiencing headaches or dizziness. Headaches are common side effects of these nootropics since they tend to produce excess .
Alpha GPC or Citicoline headaches may be transitory and could last for hours. It could occur occasionally whenever these supplements are used each time. Using Citicoline or Alpha GPC nootropics could aggravate migraines or headaches induced by other stimuli.
Various studies suggest that most individuals do not get adequate choline form their food. Supplements containing choline aid in supporting the body to convert choline into Acetylcholine in a natural manner.
Both Alpha GPC and Citicoline are sources that provide the body with the much-needed choline. After crossing the blood-brain barrier, choline gets broken down, and Acetylcholine is created as a derivative. Acetylcholine is a neurotransmitter that improve memory, learning, analysis, attentiveness, and focus.
Both Citicoline and Alpha GPC nootropics are responsible for the activation of the acetylcholine receptors in your brain. However, some clinical studies show how the overdose of these supplements might put excessive strain on the cholinergic system leading to migraines and headaches.
In contrast, if one lacks choline in their nutrition, they could suffer from acetylcholine deficiency and headaches. That is why nootropic users taking choline supplements stack it with racetams (Piracetam. Staking choline with Piracetam) to reduce such effects.
Excess use of Piracetam could leave to increased choline craving. which, if not addressed in proper amounts, could lead to headache symptoms.
Taking Citicoline and Alpha GPC in excess or in small amounts can lead to headaches. Smaller-than-recommended-doses can lead to a migraine-like feeling as a result of acetylcholine depletion in the brain although higher doses can can lead to the same effect (the headache tends subside quickly). It’s recommend to lower the dosages immediately or completely stop intake.
If headaches persist after cutting choline intake, then it could be a natural compatibility between the user and nootropic. Going for natural sources of choline is a healthy option. These are found in:
Another option is to go for other nootropics with diverse mechanisms that downplay headaches symptoms while enhancing cognition. These nootropics are racetams (Piracetam, Aniracetam, and Oxiracetam) and natural nootropics (acopa Monnieri, Galantamine, and Huperzine A).