Ampakines nootropics are arguably the most potent supplement in its class. At present, several clinical tests are still underway regarding its effects on brain functionality. Some of these test results are quite encouraging and reveal numerous cognitive benefits.
Some of the familiar Ampakines benefits include , better memory, improved learning abilities, improved attentiveness and high cerebral energy. Furthermore, the effects of this nootropic supplement tend to last even after it leaves your body.
The side effects of Ampakines are mild compared to other nootropic supplements. Unifiram and Sunifiram are the two major ampakines. However, various other nootropics, such as Aniracetam, are also popular ampakines hybrids.
The mechanism of action of the Ampakines supplement is unique. These nootropic compounds tend to transform the portions of your brain called AMPA receptors. The roles played by these receptors include organizing channels, and controlling and managing the synaptic communications between the nerve cells. These receptors also regulate most of the CNS (Central Nervous System) activities.
Medical scientists found that Ampakines receptors didn’t need any force to work faster. However, these appear to adjust so as to permit this likelihood when required. The consequence of this activity was a lot of effects which were quite similar to a stimulant. But these results lacked any of the annoying side effects (such as anxiety or sleeplessness) commonly associated with other nootropic supplements.
Ampakines also assist in stimulating various other receptors. In reality, both AMPA and NDMA receptors rely on the glutamate neurotransmitter to work appropriately. Ampakines supplements activate both of these receptors.
When Ampakines activate AMPA receptors, it leads to the improvement of rapid, excitatory communications. Ampakines tend to delay the deactivation process and ease the desensitization of the effects of AMPA receptor. It even facilitates LTP (Long-term Potentiation). Ampakines also stimulate the formation of neurotrophic factors, for instance BDNF (Brain-derived neurotrophic factor).
Recent studies are focusing on searching for a secure way to regulate both the receptors – AMPA and NDMA – efficiently. Scientists believe that regulating these receptors will result in a medicinal breakthrough. It will help in the treatment and prevention of various degenerative cognitive disorders, such as Alzheimer’s and dementia.
However, it also raises some concerns, such as excitotoxicity. Fundamentally, when Ampakines stimulate glutamate receptors, more of this substance gets formed. As a result, your brain engages in surplus activities. Due to this, the nerve cells also get excited and can easily burn themselves out.
It’s a big concern as surplus glutamate actions can result in nerve cell burnouts and even death of neurons. However, there exist some nootropics which might help to control this condition by stacking them with Ampakines.
Various types of Ampakines are available on the market. The following is a list of the top Ampakines nootropics:
Sunifiram: Also called DM-235, Sunifiram is a piperazine compound which is a derivative of Piracetam. Piracetam is among the top nootropics for memory. Sunifiram and Piracetam have similar chemical composition, but Sunifiram is comparatively more potent. As a result, its effects are more potent even at lower dosages. Sunifiram tends to activate AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors. It leads to the improvement of rapid, excitatory communications and LTP (Long-term Potentiation). LTP means the fortification of synaptic neurotransmissions over time, which leads to improved memory.
That is how Sunifiram helps to decrease cognitive decline. Sunifiram is a capable Ampakines drug for the treatment of various neurodegenerative diseases like ADHD, Alzheimer’s, schizophrenia and Parkinson’s disease. Further studies are still going on to fully understand the benefits of Sunifiram for the treatment of other cognitive disabilities.
Unifiram: Also known as DM232, Unifiram generated results which were quite similar to Sunifiram during its clinical trials on animals. Unifiram successfully repressed memory disorders by scopolamine during the passive avoidance test just like Sunifiram. Unifiram was also able to considerably decrease the overall sleeping time stimulated by pentobarbital during a similar test on mice.
This Ampakines class is also known as Ampakines cortex pharmaceuticals. Cortex Pharmaceuticals Company, based in the US, is currently researching and manufacturing the Ampakines CX Class. The research work is mainly targeting ADHD and Alzheimer’s treatment. The studies are going on for more than a decade. And several humans and animals went through many tests on numerous clinical projects.
Ampakines CX-516: Also called Ampalex, Ampakines CX-516 was among the first Ampakines supplements, which was initially developed and studied by the Cortex Pharmaceuticals Company. Regardless of the outstanding results demonstrated by the clinical tests on animals, the trials on humans showed low effectiveness.
Ampakines CX717: Ampakines CX717 is a powerful version of Ampakines CX Class. The manufacturers of CX717 believe that this variety is way more potent than all of its predecessors. It has been proven to be a breakthrough in the treatment of both ADHD and Alzheimer’s disease. The research work conducted by the company reveals that CX717 is a highly effective supplement. However, the FDA is still conducting its research. The agency seems concerned with tissue toxicology during the clinical trials on animals. However, the company claims that humans can safely use CX717.
Ampakines LY-404187: Eli Lilly developed the latest Ampakines supplement called LY-404187. Recent studies reveal that this supplement can efficiently activate BDNF protein. This protein is extremely helpful for the creation of new nerve cells and synapses which can boost long-lasting memory. The clinical trials on animals revealed that LY-404187 supplement could immensely improve your brain’s cognitive abilities. Further tests are going on to check whether or not this supplement can treat ADHD, Parkinson’s disease, and Schizophrenia.
Ampakines are providing promising results in improving cognitive abilities during several clinical trials on mice and some humans. Ampakines are ideal supplements for curing various cognitive deterioration-related diseases. The effects of Ampakines are helpful for the treatment of those cognitive disorders with decreased glutamate-mediated excitatory activation levels. These disorders include schizophrenia and Alzheimer’s disease. Further research is still on-going to understand how Ampakines benefits brain functionality. The studies will also determine the safety and effectiveness of these supplements in the long run.