Modafinil and Adrafinil are two of the most popular smart drugs available on the market today. Many people use these cognitive enhancers for memory productivity and general alertness. Despite contributing to similar effects, Modafinil and Adrafinil have some key distinctions between them. To help determine which is the better nootropic for you, let’s take a closer look at their differences.
Modafinil and Adrafinil have very similar structures at a chemical level. However, the human body processes them in two very disparate ways.
The body processes Modafinil through metabolic activities that occur mainly in the liver. We rely less on enzymes to break down Modafinil. On the other hand, our bodies are highly dependent on enzyme activities () to process Adrafinil correctly and efficiently. The liver utilizes these enzymes to convert Adrafinil into Modafinil. How quickly the liver can change Adrafinil depends on the metabolic rate and health of the liver.
Therefore, the most significant difference between Modafinil and Adrafinil is that the former requires less use of the Cytochrome p-450 enzymes.
Because Adrafinil requires a lot more enzymes to convert into Modafinil, it must be taken cyclically over time to avoid the build-up of such enzymes within the liver. Prolonged use could potentially be harmful to the health of the organ. You should take Adrafinil three times per week for no longer than five consecutive months to avoid potential damage to the liver.
The recommended dosage for Adrafinil is between 600 to 1200 mg per day. As with most other supplements, you should start with a low dosage and monitor your body’s reactions and tolerance before increasing the amount. You should avoid consuming Adrafinil in the afternoons and evenings to avoid sleepless nights.
As Modafinil does not transform within the liver, it requires a lower dose than Adrafinil to reach its optimal potency. Modafinil comes in 100 mg or 200 mg tablets and the recommended dosage is 200 mg per day. You should take it once a day, ideally, in the morning. However, if you are just starting to take this smart drug, your initial dosage should be 100 mg per day. Your body needs to get accustomed to the drug before you increase daily intake.
Modafinil and Adrafinil were developed by the same company to treat the same medical conditions. Both drugs enhance the dopaminergic and noradrenergic systems to produce vigilance, alertness or wakefulness.
Modafinil is a wakefulness-promoting agent (eugeroic) with the primary function of treating sleep disorders or excessive daytime sleepiness. It stimulates the Central Nervous System (CNS) to increase both mental and physical energy levels. Users reported experiencing results in a consistent and smooth level rather than a short burst of energy like the effects of caffeine and other amphetamines. It is also a little more fast acting than Adrafinil because it does not need to transform in the liver. Its effect also lasts slightly longer.
Adrafinil is a prodrug that metabolizes into Modafinil, resulting in similar effects. One of the most significant benefits of Adrafinil is its ability to normalize sleep patterns. Additionally, Adrafinil enhances the levels of dopamine and serotonin within the brain. With the increase in these neurotransmitters, which have links to the sensation of pleasure, users can achieve mood enhancement.
Within the recommended dosage, Modafinil and Adrafinil are generally safe. They have almost the same potential side effects, including inervousness, headaches, nausea or gastrointestinal problems. There have been reports of an increase in blood pressure and even cardiac issues when users take high doses of these supplements.
However, when users consume Adrafinil excessively, there is a risk of liver damage. Therefore, we can see Modafinil as the safer drug in this sense.
Adrafinil is unregulated and is legal in the United States and the United Kingdom. The United States do not consider it to be a prescription-worthy drug and do not control it under any act of Congress. You are free to purchase it easily, either over the counter or online.
On the other hand, Modafinil is heavy regulated. The United States classified it as a Schedule IV drug which requires a prescription. It is also a prescription drug only in the United Kingdom.
Although Modafinil is a bit safer on the liver and more fast acting, Adrafinil is much easier to obtain without a prescription. However, it is always best to consult a medical professional before starting the use of any nootropic and users are advised to stay within the recommended dosage.