Piracetam and aniracetam are both racetam supplements that enhance cognitive performances with neuroprotective qualities. Although they are similar at a chemical level, small changes can have significant impacts on their interactions with the human brain. Having a clear understanding of how each of these drugs work can help you decide on the best nootropic supplement routine for you as an individual.
Piracetam is the model drug for the other racetams and has a well-established history of being non-toxic and safe to consume at recommended doses. Being older than Aniracetam, scientists have conducted more studies on piracetam than most other racetams.
Some scientists believe that piracetam restores the membrane fluidity of degraded neuronal cells. According to other hypotheses, piracetam moderates steroid sensitive protein synthesis, which is key to memory storage and consolidation.
People new to racetams should start with piracetam and monitor for any adverse side effects before moving on to aniracetam. Users who want to have cognitive enhancement over a long period should consider using piracetam as it is less potent than aniracetam.
Aniracetam is also a safe cognitive enhancer. It promotes the formation of new synapses in the human brain and enhances the synaptic plasticity. It is an excellent supplement for people who suffered damages to the brain dementia, Alzheimer’s, trauma, and other similar conditions. Aniracetam is lipophilic (dissolves in lipids or fats) so it can give an intense burst for improving concentration and focus.
The benefit of the entire racetam family primarily focuses on memory and learning. However, there are differences in the benefits that both piracetam and aniracetam can give.
With piracetam, the user can experience an increase in memory ability, especially in memory formation, consolidation, and recall. It also improves learning ability over time. Users of piracetam say that they can focus better and for longer periods of time after using the drug.
People use aniracetam to boost memory and concentration while also as an anxiolytic (anxiety reducer). There are some reports of people experiencing an enhanced sense of perception with this racetam including seeing an increase in the richness or saturation of certain colors.
Depending on the size and tolerance of the user, the suggested dosage for piracetam is around 1.5 to 6.5 g. While toxicity is usually not a problem, higher doses can cost more money in the long term without providing any additional benefits. Efficacy studies show that 4.8 g per day is suitable for piracetam.
The recommended dosage for aniracetam is 0.75 to 4.5 g, which is lower than piracetam’s suggested dosage. Because aniracetam possesses a powerful but short effect, it can be taken up to four times per day with smaller doses. Effective treatment for dementia utilized is 1.5 g per day.
Studies of both aniracetam and piracetam show tremendously high toxicity levels in humans and rats. A high toxicity level means that it is only toxic to humans when the amount ingested is extremely high. Even with extreme doses of either piracetam or aniracetam, there are relatively few side effects. This is one of the reasons that many nootropic users utilize both racetams as parts of a combined treatment for many different conditions.
Many users have reported that co-ingesting piracetam and aniracetam produced a more profound overall effect than when used isolation. Apart from its subtle enhancement to the users’ cognitive state, piracetam also helps to augment the effects of other racetams. Scientists think that piracetam opens the oxygen pathways within the cerebral cortex while aniracetam improves memory and concentration.
Piracetam acts by stimulating the acetylcholine receptors and enhancing communication across the corpus callosum (a band of nerve fibers linking the two hemispheres of the brain). Meanwhile, aniracetam stimulates the AMPA receptors which mediate fast synaptic transmission in the central nervous system (CNS). As a result, users can achieve a sense of heightened focus.
Furthermore, while piracetam helps with memory formation, aniracetam increases recall of that information at a faster processing rate. Subsequently, some users say they feel more efficient at processing the information which they are studying or working on.
You can get the best of both racetams by merging the longer term cognitive enhancing effects of piracetam with the shorter term cognitive improving and mood-boosting effects of aniracetam. However, do make sure to reduce the dosage of both drugs when stacking.