Hordenine is a naturally occurring compound that exists in different plants. Hordenine was first created in 1984 by a German pharmacologist who extracted the alkaloid from a cactus, which he named “anhalin”. In 1996, another scientist independently obtained an alkaloid from germs of barley seeds and he called the substance “hordenine”. After that, an Austrian chemist named Ernst Späth discovered that these two alkaloids had identical chemical structure and kept the name “hordenine”.
Phenylethylamine, or its abbreviated name PEA, is a monoamine alkaloid and can affect many neurotransmitters like serotonin and dopamine. PEA is famous for its ability to alter the brain’s functions to influence consciousness and mood.
Stacking hordenine and PEA together is rather common for nootropic users who want to boost their mental energy and achieve better mood.
Hordenine is a compound that can cross the blood-brain barrier and affect the . According to examine.com, this substance can act as a noradrenaline reuptake inhibitor as it can enhance adrenaline-induced contractions without causing contractions. It is subject to metabolism by monoamine oxidase subset B (MAO-B) and, to a minute extent, by MAO-A too.
PEA is a trace amine that is also able to cross the blood-brain barrier efficiently and can be taken up evenly across most areas of the brain. As phenylethylamine can encourage the release of “happy hormones” like serotonin and dopamine, some users may experience a sense of euphoria while taking it. Like hordenine, it is also primarily deaminated by MAO-B.
With its ability to influence the adrenaline system, many people utilize hordenine as both a mental and physical energy source. Furthermore, this supplement can help subdue appetite. Combined with its power to raise your adrenaline level, hordenine is effectivein helping you to lose weight.
PEA’s role in stimulating the release of dopamine and serotonin makes it a potent drug for users who have the need for a mood boost. Apart from this, it can also significantly improve focus and communications between nerves. Many users have reported the immense effectiveness of phenylethylamine. However, its biggest shortcoming is that the impact is relatively short, with a half-life of less than a minute due to the metabolization by MAO-B. This is the reason why many people look for ways to prolong PEA’s efficacy in a safe way.
PEA and hordenine have a synergistic relationship, which means that, when taken in concert with each other, their effects are more pronounced than when consumed separately. One of the reasons is because they are both mainly subject to deamination by the same substance, MAO-B. When stacked together, the MAO enzymes will metabolize hordenine, resulting in the protection of PEA from deteriorating too quickly.
Another advantage of this stack is that it is an excellent combination to take as a pre-workout supplement. It can make intense exercise more efficient by enhancing energy and maximizing fat burning. Furthermore, it does not have the undesirable side effect of jitteriness which many other stimulants like caffeine could produce.
If you would like to start on the hordenine PEA stack, a good initial dosage is 15 mg of hordenine and 300 mg of PEA. You can consume hordenine 20 – 30 minutes before taking the PEA dose. This method allows enough time for hordenine to bind to the MAO enzymes so the effects from phenylethylamine can last longer. If you do not observe any effect or experience only a minimal benefit from this dosage, you can increase it to 30 mg of hordenine and 500 mg of PEA.
As with all nootropics, you should always monitor your body for any adverse effects when starting a new stack. In case you observe a rapid or abnormal heart rate, you should lower the dosage. If you are taking any strong stimulants, it is advisable to refrain from taking this stack. You should also avoid both PEA and hordenine if you are currently on any medication that alters your blood pressure.
At the moment, both of these drugs are unscheduled and are legal. However, it is always best to consult a medical professional if you are looking to start any new supplement regimen.