Alpha GPC (or L-Alpha glycerylphosphorylcholine) is a very powerful nootropic supplement and is considered to be one of the best choline sources available for public consumption. Alpha GPC is able to easily bypass the blood-brain barrier and deliver the choline, stimulating the production of the powerful neurotransmitter acetylcholine which governs cognitive ability and memory retention as well as processing ability.
Alpha GPC is actually found naturally, at minute levels in red meat, and in our bodies with trace amounts in our neurons. Certain studies have estimated that as many as 90% of the world population receives a deficient amount of choline and, thus, Alpha GPC is set to be a useful stimulant for any diet. After delivering the choline it , forming acetylcholine. It is free of most toxins that are by-products of these reactions.
As the most reliable and safe deliverer of choline, Alpha GPC has been studied extensively over the years, and has a wide range of possible benefits, generally improving mental health, cognitive ability as well as having a stimulating effect in general. It can increase blood flow to the brain and cause more sugar to be metabolized for energy, leading to better mental and physical health. A few of these benefits are as follows.
Academic research across decades attests to choline’s effectiveness in regards to improving memory across the board. Choline triggers the production of the neurotransmitter acetylcholine; the process towards memory formation and retention is streamlined as a result. As the best source of choline available, Alpha GPC benefits both short term memory (fluid intelligence) and long term memory (crystallized intelligence).
Fluid intelligence deals with adapting to situations, finding patterns and identifying new solutions to problems. Crystallized intelligence refers to the ability to use learned knowledge and apply it to different situations.
Furthermore, there is evidence regarding Alpha GPC as a neuro-protector that protects the body from losing memories. We do not understand our brains enough to understand why we lose memories, but one possible factor is a deficiency in choline. Choline has been administered immediately after severe head trauma and has resulted in the recovery of memories to a large extent.
With regards to treatment of Alzheimer’s, choline is infamous. Some have hypothesized that since Alzheimer’s is associated with an increased rate at which protein lipids disintegrate. This disintegration is believed to be behind choline deficiency, a fact that leads us to assume that Alzheimer’s may cause an increased demand for choline for the purposes of retaining memory.
Among all sources of choline, there is a belief that Alpha GPC, which disintegrates in the blood stream in a unique manner referred to as auto cannibalization and bio accumulates on the lipids, may inhibit the growth of Alzheimer’s. A dosage of 1,200 mg of Alpha GPC in divided doses has been seen on a number of studies to improve cognitive symptoms of people suffering from Alzheimer’s, even those who have cognitive decline lasting years.
As such, Alpha GPC is a chemical which seems to be the most effective medication for long-suffering Alzheimer’s victims. Whether it has the potential to defeat the disease is a matter of much study.
Alpha-GPC improves the flow of blood to the brain, boosting mental health and energy to a large extent. It has been demonstrated that, after a few months of sustained medication, the subject is capable of a 14% increase in physical strength 45 minutes after taking a standard dose. The specific power test used in this study was bench throws.
It is believed that choline stimulates the hypothalamus, thus increasing the production of growth hormone, improving physical strength and size. This has led to several athletes being interested in using the chemical. Though there are some studies that seem to prove this claim, Alpha GPC has been shown to increase production inconsistently. But HGH normalizes within 2 hours and its practical benefits are limited. By improving blood flow, the chemical also stimulates oxygenation of the brain, causing an uptake in brain health.
The possibility of Alpha-GPC countering obesity is a subject of study.
Alpha GPC has been clinically used in conjunction with other nootropics for victims of strokes and ischemia. A trial of 2848 patients noted that a month of intra-muscular injection of the drug followed by 5 months of oral consumption noted improvement across the board in all memory functions. The rate of recovery of the patients improved, and their cognitive abilities were seen to be 22% improved compared to the control group. They recovered more thinking skills. Similarly, it is said to improve symptoms of vascular dementia, including behavior, mood and thinking skills.
There is further evidence that administering Alpha GPC immediately after a stroke leads to the chemical acting as a neuro-protector. Victims of stroke often have holes in their memories and Alpha GPC can protect the brain from losing these memories. Since most of the trial used intra-muscular injections, it is uncertain how much benefit there will be from oral treatments alone.
Probaby the most prominent of choline’s uses is its role in arresting cognitive decline. Scientists have argued that 90% of the world’s population has a choline deficiency, and this choline deficiency results in loss of energy and stamina, loss of memories and decreased cognitive ability. Cognitive decline has been something we have always assumed comes with age, but it could be that, as we age, choline is not being produced in the body to a sufficient extent. Scientists urge everyone to use choline as an artificial supplement.
Further, Alpha GPC is a phospo-lipid itself, the same material as the membranes in our brain. After delivering choline it disintegrates and begins to reinforce this membrane, thus encouraging better brain health in the long term. The chemical naturally reinforces the barriers of the brain that prevent loss of memory and even physical strength.
Studies have demonstrated without doubt that a high dosage of Alpha GPC (1200 mg per day) reduces the rate of cognitive decline, whether degenerative or vascular.