2C-D Nootropic, Its Benefits, Dosages, Effects and Side Effects


2C-D, which is also known as 2, 5-dimethoxy-4-methylphenethylamine, is a psychedelic drug and a member of the 2C family occasionally classified as Nootropic. It is often used as an entheogen.

It was first synthesized by a team from the Texas Research Institute of Mental Sciences in 1970.

Alexander Shulgin was the first person to investigate the use of 2C-D in humans. He lists the dosage range as being from 20 to 60 mg in his book PiHKAL (Phenethylamines I Have Known And Loved), but many people recommend higher doses. Lower doses of 2C-D have been investigated as a potential nootropic although with mixed results.

Alexander Shulgin referred to this material as a “tofu,” which means that when joined with other substances, it can lengthen or prolong their effects without coloring the experience too much, in a manner similar to how tofu takes on the flavors of sauces or spices it is cooked with.

A group of people experimented with 2C-D, specifically in regards to its effects on learning and cognition. In the mid-1980s, they used graduate students who were voluntarily taking 2C-D as volunteers and recorded the outcome when they took this drug. The result was remarkable: “Certain Exotic Transmitters” offered increased mental capacity in their observations.

It appears that Alexander Shulgin’s research was confirmed in the end with the best nootropic effects taking place somewhere in the range of 5-15 mg per dose.


The benefits consist of mostly psychedelic or nootropic usages. The dispensation of this supplement helped to expand learning capacity, improve memory and increase the speed of memory recall as well as attention switching to bolster focus and concentration.

  • It leads to increased mental clarity in some cases as well as overall cognitive enhancement.
  • With moderate doses, you will likely experience increased sociability, philosophical insight and introspection.
  • All these can be considered cognitive enhancing benefits even though the supplement was not created for this purpose.
  • Furthermore, 2C-D helps to induce pleasurable feelings which are typically associated with the use of psychedelics. This may include having mental and physical stimulation, quite possibly to the point of experiencing euphoria. Others reported feelings of empathy and enhanced tactile sensation.
  • There may be some mild elevation in heart rate and, perhaps, an increase or decrease in sexual arousal; it all depends on how the supplement affects each individual.


Dosages are solely dependent upon the reason that the user wants to take 2C-D; for nootropic or cognitive enhancing effects it’s advisable to use small or medium doses.

  • Based on Alexander Shulgin’s research it would be 10 to 15mg. In Alexander Shulgin’s book, he stated that the 10mg level turned out to be great for instigating typical “smart drug” effects while 20mg seemed to be the right dosage for having a stimulant effect.
  • Moreover, there isn’t enough evidence as to whether or not 2C-D is a supplement that can be taken daily. The legal status of 2C-D is quite unclear, but in the United States 2C-D is potentially covered under the Federal Analog Act which means that Selling or purchasing 2C-D with the intent of human consumption is potentially punishable as an offence.  
  • 2C-D could likely be used in other nootropic stacks. It has been compared to tofu because of its ability to take in whatever other ingredients it is mixed with. That is to say, it might be useful in terms of making other supplements even more productive.

Effects and Side Effects

2C-D is taken orally, though it may also be taken nasally (insufflated). Insufflating tends to cause severe pain, however, and the dosage quantity is usually much lower, typically in the region of 1 to 15 mg. There isn’t much information given on the toxicity of 2C-D as major studies have been conducted.

However, since it is believed to be a psychedelic compound derived from phenythylamine (a natural chemical found in the body that you might not know as a nootropic), it may exert effects through the modulation of a number of neurotransmitter systems.

The effects of 2C-D typically last for 4–6 hours, according to Alexander Shulgin.

  • The chance of having a side effect as with other stimulants increases with higher doses. It could lead to dizziness, headaches and distractions while others may experience anxiety, nasal discomfort if insufflated and much more. In the more serious cases, the side effects may include sweating or chills, paranoia or even severe mental confusion.
  • Some people claim 2C-D is relatively uninteresting on its own while many others strongly disagree with this judgment, considering 2C-D to be a true psychedelic in its own right.

This is a drug with limited research history, so it isn’t advisable to take 2C-D unless you are under the supervision of a medical professional.

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Erica Silva
Senior Editor
Erica Silva is a blogger by choice. She loves to discover the world around her. She likes to share her discoveries, experiences and express herself through her blogs. Currently, she is associated with DementiaTalk Team.

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