Agmatine Sulfate is a biogenic amine derived from the amino acid L-Arginine. It occurs because of a process decarboxylation, a chemical reaction that releases carbon dioxide, removing a carbon atom for a carbon brain. As a result of this compound’s unique storage mechanism, Agmatine Sulfate possesses actions and abilities that its predecessors lack.

Agmatine Sulfate is seen to have lasting benefits for those suffering from neuropathic pain as well as those recovering from drug addiction or substance abuse in general. It is believed to be valuable as a preventative measure against potential stroke, and is widely used to improve and/or maintain overall cognitive health. Agmatine Sulfate is also known to repair neuro-damage caused by previous stroke.

Some have touted it as a neuromodulator or neurotransmitter, effecting our metabolic pathways and a spectrum of activity in the brain.

The mechanism of action is quite simple—Agmatine Sulfate crosses the blood-brain barrier and enters in the Central Nervous System where it binds to NMDA Glutamate receptors. This is the primary neurotransmitter for memory function and plasticity which may be why Agmatine has the cognitive effects that it does.

It works to inhibit calcium channels and controls our levels of nitric oxide. It has also proven to possess analgesic qualities, dumping endorphin and opioid chemicals. Perhaps as a consequence of this, Agmatine Sulfate intensifies the effects of substances like Fentanyl and morphine. Opiate and opioid users are advised to take precautions when consuming Agmatine Sulfate. While it can work in tandem with these substances to fight pain and reduce tolerance, no one wants an overdose on their hands and users should definitely not combine Agmatine Sulfate with any opioid substances if operating heavy machinery or driving. Despite all this, Agamatine Sulfate appears to have a synergistic effect with marijuana usage.


Agmatine Sulfate is more potent than alternatives like Arginine and is, therefore, a better nootropic for obtaining that edge you want on the court or in the conference room.

Among its benefits are the following: 

  • Improved Mood
  • Anxiety Relief
  • Antioxidant Properties (By putting the kibosh on Glutamate, it occludes overexcitation of the brain)
  • Prevents Against Excitotoxicity (This is where Agmatine Sulfate gets the jump on its competitors, Unifiram, Modafinil and Sunifiram, among others)
  • Increased Muscle Mass (Agmatine enhances insulin response, thereby making it possible to build a lean and muscular body with exercise)
  • Pain Relief

Some believe Agmatine Sulfate might also influence the production of GH and LH hormones, resulting in a positive impact on body composition. Additionally, Agmatine Sulfate removes toxins and free radicals from your body, promoting better mental and physical well-being. At one time, Agmatine was being studied for its prospective anti-aging benefits, though results have either not been disclosed or are on-going.


A very minute percentile of users have reported deleterious side effects when taking Agmatine Sulfate. In a relevant study, a mere three participants in the highest dosing range experienced moderate symptoms of nausea and diarrhea. Compared to the glut of adverse effects many nootropics and pharmaceuticals induce, Agmatine Sulfate’s rare side effects are a walk in the park…or to the bathroom.


The average dosage levels are between 250 mg to 1,000 mg per scoop. The recommended daily dose is between 1 and 2 grams. Users are encouraged to stick to the recommendations on your supplement’s label and to start at the lower end of the spectrum. For information on contraindications and more about this exciting compound, please click here.

Erica Silva on Twitter
Erica Silva
Senior Editor
Erica Silva is a blogger by choice. She loves to discover the world around her. She likes to share her discoveries, experiences and express herself through her blogs. Currently, she is associated with DementiaTalk Team.

Comments are closed here.