Alpha GPC Side Effects and Drug Interactions

Alpha GPC Side Effects and Drug Interactions

Alpha GPC Side Effects and Drug Interactions

Alpha GPC refers to a prescription drug, which is used in Europe to treat Alzheimer’s disease. You can find it in two forms – the first one can be taken by mouth while the other comes in the form of an injection. In the US, however, Alpha GPC only serves as a dietary supplement, and you can usually find it in

products designed to improve memory. Some other benefits of this drug include treating dementia and mini-stroke and improving your thinking skills, learning and memory.

Despite its sundry benefits, Alpha GPC also has some rather unfortunate side effects. Take note of the following negative effects of Alpha GPC, so you will know if it’s safe for you:


One of the most common side effects of taking Alpha GPC is headaches. Some users say that regardless of the dosage they take, they still experience slight fuzziness and headaches. Some experts cited supplementation with alpha GPC as one of the major causes of these mild headaches. The good news is that this effect is generally mild, thus it should not be a cause of any real concern.


There are also those who complain about suffering from insomnia or excitation after they start taking alpha GPC. This is mainly because the drug contains acetylcholine, which is a mild stimulant for the central nervous system. Those who are sensitive to stimulants will most likely experience insomnia or difficulty falling asleep at night once they start to make alpha GPC a part of their routine.

Other Potential Side Effects

Aside from insomnia and headache, some of those who take alpha GPC also report that they experience fatigue, gastrointestinal distress, diarrhea, nausea and nervousness. There are also those who say that they experienced low blood pressure and dizziness due to the supplement. These negative side effects often result from taking a high dosage of the supplement.

Extremely high doses can also lead to decreased appetite, stomach issues,  heartburn, confusion, sweating and salivation. In case you encounter any of the abovementioned side effects, it would be best to lower your doses or consult your doctor immediately.

Drug Interactions

While Alpha GPC is safe when used with the majority of other medications and supplements, it is still important to watch out for one drug interaction that comes with it. This is Scopolamine, which seems to interact with Alpha GPC. If you are taking the former, then make sure to consult your health provider first before taking Alpha GPC. The interaction is only mild, but it’s best to be on the safe side by avoiding the combination as much as possible.

Scopolamine is known to directly work against one of Alpha GPC’s active mechanisms. It blocks acetylcholine, a neurotransmitter, which Alpha GPC intends to make more effective and active. It remains unknown whether this can reduce the effectiveness or benefits of the drug or if it solely blocks Alpha GPC’s effects.

If you have a present health condition or if you are taking other medications, it would be best to talk to your doctor first before taking the supplement so you will know if it is safe for you or if there are any unwanted interactions.

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Erica Silva
Senior Editor
Erica Silva is a blogger by choice. She loves to discover the world around her. She likes to share her discoveries, experiences and express herself through her blogs. Currently, she is associated with DementiaTalk Team.

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