Coluracetam is a synthetic racetam, better known as MKC-231. It is used to improve mental capacity and enhance mental well-being. Like any other nootropic, it works by crossing the blood-brain barrier and helps the person experience a rush and a calming effect in the brain.  

Most people use Coluracetam to boost brain activity. However, not a lot of research has been done on the drug, so it is not an assured cure for improving cognition.  

Coluracetam can be combined with other nootropics and consumed to enhance mental capacity. It can be bought over the counter without a prescription and is also available online. This drug is mostly sold as a capsule but is also available in powder form for consumption.

How does it work?

As mentioned earlier, Coluracetam is a nootropic that is used to enhance cognition. Cognition refers to our mental capacity, and how much information can be absorbed and utilized by the brain.

Due to lack of proper information on the functioning of this drug, it is still unclear as to how it works on the mind.  Research indicates that the drug aids in choline acceptance, better known as high-affinity choline uptake. Broadly explained, it refers to the uptake of choline that is absorbed by the neurotransmitter acetylcholine. This increases the cholinergic neurons in the brain, thereby enhancing cognition.  

Coluracetam also helps in reducing learning difficulties. Those who find it tough to comprehend situations and have little clarity in understanding can consume it for better cognition.

Coluracetam is also used to induce a mental calm. It particularly helps people who are exposed to stress and anxiety or have anger issues. The drug usually works within a couple of days and effectively soothes a person’s nerves.   


  • Like most other nootropics, the biggest benefit of Coluracetam is memory improvement. It supports cell health and prevents erasing of memories. It is ideal to combine the drug with another nootropic as that can further help enhance memory power.  
  • Coluracetam improves focus. Many people tend to get distracted easily, owing to a large number of distractions that surround them. A good way to deal with this is by consuming a nootropic like Coluracetam as it can help in enhancing mental alertness.
  • Those suffering from borderline Alzheimer’s can turn to this drug for relief. The drug works by improving mental capacity and counteracts some of the side effects of the illness. However, it is advisable to continue your regular medication and not depend on this nootropic alone to help you out. (Best to consult physician)
  • Coluracetam is said to enhance physical stamina. Consuming it on a regular basis can help with improving your body’s capacity to take up physical activity. Those who work out regularly will find it easy to push their limit and exercise more vigorously. It can be used as means to boost strength and develop a lean body.  
  • Some people consume Coluracetam to help control anxiety and its side effects. Anxiety can lead to panic disorders, and the best way to deal with it is by consuming drugs that induce a calm state of mind. Although this nootropic increases mental alertness, it starts to calm the mind down after an hour or so of consumption. It can, therefore, be consumed at night to induce a good night’s sleep.  
  • Students use the nootropic before an exam to both enhance focus and boost memory. Doing so can help in understanding matter and remembering things for longer.  
  • The drug is said to help with ADHD to a large extent. Attention Deficit Hyperactivity Disorder refers to being unable to focus on any one thing and mostly affects young children. It does not have an assured cure but can certainly be curbed. One effective way of tackling this condition is consuming a nootropic such as Coluracetam. It will help the child remain focused and not cause their mind to wander. But it will take the drug a little time to show results and will not be an overnight change. It is best to consult a pediatrician on dosage and safety.
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    Side effects

    Like most other nootropics, Coluracetam also comes with its fair share of side effects. Here is a look at some of them in detail:

    • As mentioned earlier, there is not enough information regarding the effects of this drug on the body, so it is best to exercise a little precaution. Be alert on the dosage as an overdose can cause your body to react adversely. It is best to remain within the recommended dosage level.  
    • You might experience dizziness and nausea after the first few intakes, but that is a common occurrence for most users. If the condition persists, it might be best to discontinue the drug or reduce the dosage.
    • In some cases, the user experiences headaches, but with regular use the intensity diminishes. If the pain persists after a week or two, then you can reduce the dosage or discontinue the drug.  
    • Some people complain of diarrhea after consuming the drug. If you experience the same, then it is best to stop the drug.  
    • It is advisable for pregnant and lactating women not to consume the drug as there is no evidence to prove its safety.  

    Most of these side effects are mild and don’t last for long. In any case, it is best to consult a physician with regards to appropriate dosage and other precautions.

    If you are combining the drug with other nootropics, it is best to check if the two are compatible with each other. Most people stack Coluracetam with L-Theanine as the latter is pretty mild and goes well with other nootropics.  

    Dosage and recommendations

    It is recommended to consume 100 mg of the drug thrice a day if you suffer from extreme anxiety. If you are new to nootropics then you can start with 20 mg a day and eventually increase the dosage, depending on how your body reacts to it.

    If you have already tried them before and your body is used to it, you can safely consume 200 mg a day. Do not consume any more than 300 mg as there is not enough research to know how such a dose will affect your mind.  

    Legal status of the drug

    Coluracetam is legal and you can buy it over the counter. You will not require a prescription for it. You can order it online or from your local pharmacy.  

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    Erica Silva
    Senior Editor
    Erica Silva is a blogger by choice. She loves to discover the world around her. She likes to share her discoveries, experiences and express herself through her blogs. Currently, she is associated with DementiaTalk Team.

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