The Piracetam, Oxiracetam & Aniracetam Stack

The Piracetam, Oxiracetam & Aniracetam Stack

Piracetam, aniracetam and oxiracetam are the three most popular drugs within the racetam family. Therefore, it comes as no surprise that some people take them as a stack known as the PAO stack. Ingesting all three racetams not only gives you the benefit of each racetam, but it is also synergistic for cognitive enhancement and increasing overall mental performance. Furthermore, each of these smart drugs has a different half-life, resulting in a higher frequency of dosing with one and lower with others. The user can stack them together to achieve a longer duration of effect before dosing again.

Understanding how each of these racetams affects you can be useful in guiding your expectation of this combination.


Being the oldest and most known racetam, scientists have conducted more studies on piracetam than both of the other drugs in this stack. Piracetam is well-known for being a safe and non-toxic drug when users consume it within the recommended dosage.

Most people take piracetam for memory enhancement and learning improvement. It helps with memory formation, consolidation and the rate of recall. It also enhances learning ability over time. Users of piracetam have reported being able to focus better and for longer periods of time.


Scientists believe that aniracetam stimulates the serotonin and dopamine receptors which have links to causing mood and anxiety disorders. Therefore, aniracetam may function as an anxiolytic that inhibits anxiety in some people.

This supplement also helps with increasing focus. Users of aniracetam have reported a longer attention span and being able to concentrate more easily. It is more potent than piracetam and, being a fat soluble nootropic, it has significantly better penetration of the blood-brain barrier than most other racetams which are water soluble.


Unlike aniracetam, oxiracetam does not work on neurotransmitters like dopamine and serotonin receptors. Oxiracetam stimulates the AMPA and NDMA receptors that contribute to the speed of synaptic transmission in the central nervous system (CNS).

Many users contribute an increase in their ability in logical thinking, analytical processing and understanding mathematical or scientific concepts to oxiracetam. However, it does not seem to have an effect on mood as some other racetams do.

The Stack Benefit:

The benefit of the entire racetam family mainly focuses on enhancing learning and memory. However, there are differences in the benefits that each of the racetams within the PAO stack can provide.

Many people take piracetam for long-term improvement of learning and focus. Aniceteram helps with boosting mood and reducing anxiety. Add that in with oxiracetam’s ability to stimulate the CNS for increasing processing power, it comes as no surprise that the PAO stack is quite popular among experienced nootropic users.

When taken together in a combination, the PAO stack amplifies the benefits of each racetam. Piracetam can optimize the unique effects of other racetams. Scientists believe that piracetam helps open the oxygen pathways within the cerebral cortex while other racetams carry out their respective functions.

In unison, piracetam, aniracetam and oxiracetam can offer a very potent effect as a cognitive enhancer.


Combining racetams can substantially increase the strength of the individual racetam within the stack. Therefore, users should start with a low dosage and slowly increase the amount according to their own body’s reactions to find the optimal dosage for themselves as an individual. Even if you have been taking one of the racetams in isolation and have found the best dosage for you for, you will still need to lower the dosage significantly when starting on a PAO stack supplement.

The PAO stack is not for new users of nootropics. Starting on a PAO stack without prior experience with racetams could make you overwhelmed. If you are a beginner, you should begin with just one of the racetams and analyze its effect before stacking it with another racetam.

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Erica Silva
Senior Editor
Erica Silva is a blogger by choice. She loves to discover the world around her. She likes to share her discoveries, experiences and express herself through her blogs. Currently, she is associated with DementiaTalk Team.

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