PRL-8-53: What is It?


PRL-8-53 is a synthetic nootropic drug that acts as a hypermnesic. Hypermnesic drugs are capable of enhancing cognition, memory, and treatment of certain medical conditions. Developed by Nikolaus Hansl in the 1970’s, PRL is being widely touted as the drug that aids in learning and memory retention. In a double-blind drug trial involving forty-seven healthy test subjects,  the administration of PRL-8-53 resulted in a word retention baseline rate of 205%.

PRL-8-53: Drug Mechanism

Little is known of the precise mechanisms of PRL-8-53. So far, there has only been one human study, researched and funded by Hansl himself. Participants of Hansl’s study, who initially had low test scores, showed marked improvement in memory retention. Based on the lone study, it’s possible to regulate the brain’s production of neurotransmitters, especially in the memory bank and recall.

PRL triggers the uptake of dopamine, restriction of serotonin, and potentiating response to acetylcholine. Evidence also suggests that older individuals respond more strongly to PRL than younger adults, substantiating the notion that dopamine modulation is a major factor of the drug’s beneficial effects. In animal studies, PRL-8-53 has shown to augment responses on the noradrenaline, peripherally and centrally.

Drug Benefits

Perhaps the most exciting benefit of taking PRL-8-53 is its innocuousness. In the course of Hansl’s studies, he discovered that PRL magnifies the response of acetylcholine. The said response was quantitatively comparable over a widespread dose range, thereby excluding the potential of unintended or accidental overdose.

PRL-8-53 has been shown to have any number of the following benefits:

  • Verbal Fluency (Hansl’s test subjects were made to form words; they had to form these words by using single letters and periods, for example B.S. Results showed that those who had taken the drug in the double-blind study were most capable of satisfactory output in this area of the trial)
  • Mental Arithmetic (Throughout the course of Hansl’s trial, test subjects were asked to subtract 7, add 1, subtract 7, add 2, etc. This went on until a goal was reached. More brief arrival at a goal number was observed in those who took PRL-8-53 versus the placebo administered to others participating in the study)
  • Memory (In a published study, word acquisition was chief among its findings. The administration of 5 mg of PRL-8-53 two hours before testing participants’ mental faculties produced an ability to recite twelve key words in a complicated sequence.)


Very few cases of adverse side effects have been recorded thus far. Of those that have been examined, they are rather mild in nature. These mild effects include fatigue, headache, and a bitter taste.

The biggest downer of PRL use is its lack of clinical trials and research. Due to limited study in humans, there is very little known of its long-term effects, efficacy, and potential risks. At this time, PRL-8-53 is limited in supply. It’s usually available in powder form. Synthesizing the drug is also expensive, a fact that could turn-off users who are accustomed to price-controlled nootropics.


According to, one of the leading resources for stacks, PRL-8-53 pairs best with Aniracetam, Acetylcarnitine, fish oil, and Alpha GPC. For users with allergies or pharmaceutical sensitivity, it is ill-advised to stack with Aniracetam since common side effects experienced by many include heart palpitation or irritability.

Other supplements/drugs it can stack with include DHEA, Tianeptine, Vitamin B12 (for memory), Unifaram and Melatonin (for dreaming), and IDRA-21 (for learning).

For insomnia sufferers PRL-8-53 can be stacked with Rhodiola Rosea, MCT Oil, Huperzine A, Vinpocetine, L-Theanine, Four Sigmatic Coryceps Coffee, Four Sigmatic Lion’s Mane Coffee and Phenylpiracetam Hydrazide.

Study and Pregnancy Precaution

There is slim evidence that otherwise proves PRL’s poor interaction with other substances. Lack of human studies leave a majority of the public and medical community with little proof of PRL-8-53’s risks, potentiality, and  contraindication. It is strongly advised that pregnant or lactating women refrain from taking the drug and to consult with their physician before intake.

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Erica Silva
Senior Editor
Erica Silva is a blogger by choice. She loves to discover the world around her. She likes to share her discoveries, experiences and express herself through her blogs. Currently, she is associated with DementiaTalk Team.

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