Synephrine Review


An Overview

Synephrine is an alkaloid which naturally occurs in plants. It is also known as ‘Bitter Orange Fruit’ since it abundantly originates in that plant. It has been a reliable part of ancient Chinese Medicine for last several centuries. The chemical composition of It  is very much like the ephedrine and pseudoephedrine.

Synephrine alkaloids tend to affect the adrenal system of your body and enhance the basal metabolic rate. It results in your daily caloric burning of up to 70 percent. The flowers, peels, fruits, leaves and juice of the Bitter Orange plant have been in use to develop various medicines. The peel is the primary source of Bitter Orange oil.

You can take Bitter Orange orally or can apply it on your skin. Various studies revealed that Bitter Orange oil could be specifically beneficial to your skin. It can cure various fungal skin infections such as jock itch, ringworm, as well as athlete’s foot. Bitter orange peels are also helpful for regulating appetite, weight loss, nasal congestion, stomach discomforts, and CFS (Chronic Fatigue Syndrome).

How Does Synephrine Works?

It  contains several chemicals which can influence your nervous system. These chemicals can increase the heart rate, raise BP (blood pressure), and compress the blood vessels.

Various studies revealed that Synephrine supplement could pace up your metabolism rate, which can result in weight loss. According to one study, a 50 mg Synephrine dosage improved the metabolism rate by 65 calories over the duration of 80 minutes.

The studies further revealed that such metabolic rate could considerably improve up to 180 calories. By mixing It  with other bitter orange compounds such as hesperidin and naringin, you can burn up to 180 calories. The similar quantity of calories gets burned when you run for twenty minutes. It means that additional 1,300 calories get metabolized in a single week. The studies also showed that both Caffeine and Synephrine work synergistically to boost their calorie burning properties.

Synephrine and Weight Loss

Catecholamines are the molecules which regulate your body’s calorie burning process. These chemicals bind to the fat cell receptors and stimulate the fat burning process. However, there are certain fat cells which are resistant to fat mobilization. It means that these cells don’t respond to the stimulations caused by catecholamines, and don’t burn easily.

The fat cells in your body have two kinds of receptors for catecholamines:

  • Alpha receptors (inhibit fat mobilization)
  • Beta receptors (activate fat mobilization)

These receptors are quite the opposite of each other regarding their functioning. As a result, fat cells with a high quantity of beta-receptors will easily get metabolized. And, fat cells with a large volume of alpha-receptors aren’t easy to burn.

Here, Synephrine extract can assist in burning these adamant fat cells by hindering the actions of alpha-receptors. Simply put, It  can aid in stopping these alpha-receptors from inhibiting the fat mobilization process.

It  can stimulate catecholamine activity and is even able to curb your appetite. That is why several users consider it as an efficient appetite suppressant.


Bitter Orange oil and flower are beneficial for various GI-related (gastrointestinal) issues such as:

  • Intestinal ulcers
  • Diarrhea
  • Constipation
  • Blood-feces
  • intestinal gas
  • loose rectum

Following are some additional Synephrine benefits:

  • Helps to control fat levels in the body.
  • Aids in decreasing blood glucose levels in patients with diabetes.
  • Stimulates the heart rate and blood circulation.
  • Helps the purification of blood.
  • Aids to cure gallbladder and liver issues.
  • Aids to treat bladder and kidney ailments.
  • Cures sleep-related disorders.

Weight loss: The most significant benefit of Synephrine alkaloid is weight loss. It assists in burning the excess calories by hindering the actions of alpha-receptors. Alpha receptors inhibit the fat mobilization process in your body. Several users consider Synephrine as a potent appetite suppressant as it can help to curb your hunger.

Skin infections: Synephrine can cure various fungal skin infections such as jock itch, ringworm, as well as athlete’s foot. You need to apply bitter orange oil to your skin to avail the benefits.

Diabetes: Recent studies suggest that drinking bitter orange fruit juice for about four months will help the patients with diabetes. The fruit juice seems to reduce the blood glucose levels.

Indigestion: Some reports suggest that using Synephrine products can help to cure indigestion. Synephrine, when used three times daily, together with ingredients such as Zhizhu for four weeks, can facilitate to treat indigestion-related issues.

Anxiety: Some studies even suggest that using Synephrine Extract a few hours ahead of any surgery can help to diminish the stress levels.

Side Effects

There are possible side effects which all users must be aware of before opting for Synephrine supplement. Following are some of its potential side effects:

Heart Rate: Increased heart rate is among the most recognizable Synephrine side effects. Synephrine has certain chemicals which perform the role of potent stimulants. It, in turn, enhances your heart rate occasionally to hazardous levels. Such risk increases if you combine Synephrine products with other stimulants, for instance, caffeine or energy drinks or even soda.

Dizziness: Dizziness is a common side effect of Synephrine alkaloid. It can crop up due to the variation in BP (blood pressure). The reduced blood flow to your heart can also be the other reason. It occurs as a result of thickening and hardening of the blood arteries.

Blood Pressure Issues: It  increases the heart rate, and the increased heart rate elevates the BP (blood pressure). If you’re frequently taking Synephrine supplements in excess dosages, then you might suffer from severe health ailments. For instance, the elevated BP levels can deteriorate the blood vessels which can lead to bulging aneurysm. It can also prompt your heart to function extra hard. It might result in the thickening of the heart muscle, which, in turn, can affect its blood-pumping ability.

Heart Attack Risks: It  has some stimulating effects which can enhance heart attack risks even in healthy people. Synephrine usage can lead to thickening and hardening of the blood arteries. It decreases the quantity of oxygen and blood supply to the heart muscle, which further can result in a heart attack.

Stroke: Recent report suggests that the excess use of Synephrine products can lead to the danger of having an ischemic stroke. It  comes with certain vasoconstriction properties because of which it can compress the blood vessels leading to your brain. Consequently, it can result in the escalation of an ischemic stroke.

Synephrine Dosage

Synephrine products can efficiently cure obesity issues. The recommended daily dosage of Synephrine supplement for effective weight loss is 25 to 32 mg. 

To treat fungal skin infections, you need to apply bitter orange oil daily to your skin for 2 to 3 weeks.

Synephrine Drug Interactions

With MAOIs: MAOIs (monoamine oxidase inhibitors) also known as medicines for depression interact with it. Since Synephrine contains certain compounds with stimulating effects, MAOIs medications can trigger these compounds in your body. Using MAOIs with it can result in severe side effects such as high blood pressure, fast heartbeat, fits, and anxiety.
With Midazolam: Midazolam interacts with Synephrine. Your body breaks down midazolam to completely remove it from your system. It  can reduce the pace of the midazolam breakdown process. Therefore, using It  with midazolam can enhance the side effects of midazolam.

With Caffeine: Caffeine also interacts with it. Both Synephrine and Caffeine are strong stimulants. When both are combined, these can elevate blood pressure and may increase heart rate. It can result in severe effects like stroke and heart attack.

Is Synephrine Legal?

Synephrine products are readily available. Anyone can purchase Synephrine online or over the counter without any prescription.

In the US, the FDA had banned alkaloids. However, various natural metabolic stimulants including Synephrine gained popularity as weight loss supplements. Synephrine exists in the banned-drug list of the National Collegiate Athletic Association (NCAA).

In Canada, using the combination of it and Caffeine is not legal. However, you can take Synephrine separately up to 25 to 30 mg daily.


Synephrine products are among the few proven weight loss alternatives which you can easily afford. Therefore, if you are indeed enthusiastic about losing weight, it’s worth giving a try.

However, don’t fall for the hype. It  won’t melt the entire fat in your body, although it can certainly help to metabolize more fat and calories. And, avoid combining It with other stimulants such as caffeine as it can cause severe adverse side effects.

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Erica Silva
Senior Editor
Erica Silva is a blogger by choice. She loves to discover the world around her. She likes to share her discoveries, experiences and express herself through her blogs. Currently, she is associated with DementiaTalk Team.

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