Tianeptine Side Effects and Drug Interactions


Tianeptine is a useful supplement since it treats major depressive disorder. It works in treating irritable bowel syndrome and asthma. Aside from treating mild to severe depression, it also promotes mental clarity. It can brighten your mood and reduce anxiety. Despite these benefits, it also has a few side effects. Here are some of the reported Tianeptine side effects. Most of them take place from taking extremely high doses.



This usually happens when you are still starting to take the supplement. Fortunately, this side effect will subside after you get used to it. In some cases, it also comes with vivid and complex dreams.

Risk of Tolerance and Addiction

The supplement actually has a high abuse and addiction potential. This is the main reason why you should limit your intake. Avoid consuming it every day. It’s advisable to take it once or twice per week only. Doing so will prevent you from getting addicted to its substance. Note that once you get addicted to the drug, you may experience lots of withdrawal symptoms. These include high level of excitability and anxiety.

Common Side Effects

The following are the most commonly reported side effects of Tianeptine:

  • Anxiety
  • Agitation
  • Insomnia
  • Dry mouth
  • Drowsiness
  • Dizziness
  • Irritability
  • Nightmares
  • Headache
  • Weight gain
  • Stomach pain

Less Common Side Effects

side effects

Here are some side effects that don’t usually happen, but still affect several users of the drug:

  • Heart palpitations
  • Impaired vision
  • Bladder disturbances
  • Tremor
  • Bad taste
  • Hot flashes
  • Muscle aches
  • Abnormal heartbeats

Rare Side Effects

Although rare, these side effects still affect a good number of Tianeptine users:

  • Skin allergies
  • Liver inflammation
  • Itching
  • Hypomania
  • Prolonged muscle aches

Drug Interactions

Presently, there are only limited studies about the Tianeptine’s drug interactions. However, salicylic acid can displace it from its binding sites. This can potentiate its effects. It is not also advisable for lactating or pregnant women. If you are taking certain medications like tetra-cyclic anti-depressants and monoamine oxidase, you should avoid this as well. It’s not also ideal for those below 15 years old. Those with cardiovascular diseases and kidney problems should stay away from it, as well.

Proper Dosage

Most of the Tianeptine side effects mentioned in this article are due to improper or excessive dose. This is the main reason why you need to stick to the dose recommended by your doctor. The safest is actually around 12.5 mg, which you need to take 2-3 times daily. A wise tip is to divide this dose throughout the day. This will prevent it from providing short-term effects only.

If you plan to take the supplement, it’s best to start with half or single tablet at first. This will make it easier for you to assess its effects on your body. It is also advisable to consult your doctor first. Do this, especially if you have other health conditions or are taking other medications. Your doctor can also provide you with the most accurate dosing instructions. With his guidance, you can use the supplement without worrying about its side effects.

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Erica Silva
Senior Editor
Erica Silva is a blogger by choice. She loves to discover the world around her. She likes to share her discoveries, experiences and express herself through her blogs. Currently, she is associated with DementiaTalk Team.

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